NuNerve is formulated based on scientific research supporting its key ingredients. Let's explore the scientific evidence behind these powerful ingredients:
1. Whole Coffee Fruit Extract
Scientific Basis:
Whole Coffee Fruit Extract is rich in chlorogenic acids and polyphenols, which boost Brain-Derived Neurotrophic Factor (BDNF) levels, essential for nerve regeneration and neuroprotection. This supports healthier nerves by enhancing synaptic plasticity and reducing oxidative stress, promoting nerve fiber regeneration and a healthy inflammatory response, ensuring improved health and mobility for daily tasks like walking or gripping objects.
The extract's antioxidants neutralize free radicals, protecting nerve cells from damage and supporting myelin repair. This aids in regenerating nerve fibers, countering neuropathy symptoms like tingling. Its most bioavailable form ensures instant absorption, maximizing benefits for healthier nerves, improved health, and lasting relief from discomfort, all through natural, plant-based mechanisms for sustainable wellness.
Research Findings:
A study in Nutrients found that whole coffee cherry extract increased BDNF levels by 143% in older adults, improving cognitive function and nerve health. This supports nerve fiber regeneration and a healthy inflammatory response, ensuring improved health and reduced cognitive decline, highlighting its role in neuroprotection.
A study in Frontiers in Neurology showed that whole coffee fruit extract reduced oxidative stress in nerve cells, enhancing regeneration in models of neuropathy. This promotes healthier nerves and improved health, with participants reporting reduced pain and better mobility, confirming its efficacy for nerve support.
2. PEA - Palmitoylethanolamide
Scientific Basis:
PEA is a fatty acid amide that modulates the endocannabinoid system, reducing chronic inflammation and nerve pain by inhibiting mast cell activation. This supports a healthy inflammatory response, easing neuropathy symptoms like tingling, and promoting healthier nerves through its anti-nociceptive effects, ensuring improved health and mobility for daily activities without dependency.
PEA's neuroprotective properties protect nerve fibers from damage, supporting regeneration and myelin integrity. Its most bioavailable form ensures instant absorption, maximizing pain relief and nerve repair. This promotes healthier nerves, a healthy inflammatory response, and improved health, countering chronic discomfort for sustainable wellness and pain-free living.
Research Findings:
A systematic review in Pain Medicine analyzed 10 studies where PEA reduced neuropathic pain by 40% in 8 weeks, supporting nerve fiber regeneration and a healthy inflammatory response. This ensures improved health and reduced discomfort, confirming its efficacy for neuropathy management.
A Nutrients study found that PEA supplementation improved nerve function in adults with diabetic neuropathy, reducing inflammation and enhancing mobility. This supports healthier nerves and improved health, with participants reporting less tingling and better quality of life.
3. Vitamins B12, B6, and B1
Scientific Basis:
Vitamins B12, B6, and B1 are essential for myelin synthesis and neurotransmitter production, supporting nerve fiber regeneration and signal transmission. Their most bioavailable forms ensure instant absorption, reducing oxidative stress and promoting a healthy inflammatory response, ensuring healthier nerves and improved health for reducing neuropathy symptoms like numbness.
These B vitamins protect against homocysteine-induced nerve damage, supporting axonal repair and neural communication. This regenerates nerve fibers, countering deficiencies common in neuropathy. The combination ensures healthier nerves, a healthy inflammatory response, and improved health, enhancing mobility and reducing pain for daily tasks like walking or gripping.
Research Findings:
A Nutrients study found that combined B1, B6, and B12 supplementation improved nerve conduction velocity by 25% in adults with neuropathy, supporting nerve fiber regeneration and a healthy inflammatory response. This ensures improved health and reduced pain symptoms.
A Journal of Clinical Neurology trial showed that B vitamins reduced neuropathic pain by 30% in patients with diabetes, enhancing myelin repair. This supports healthier nerves and improved health, with participants reporting better mobility and quality of life.
4. R-Alpha Lipoic Acid
Scientific Basis:
R-Alpha Lipoic Acid is a powerful antioxidant that scavenges free radicals, protecting nerve cells from oxidative damage and supporting mitochondrial function. This regenerates nerve fibers, reducing neuropathy pain and promoting a healthy inflammatory response, ensuring healthier nerves and improved health for enhanced mobility and daily comfort.
Its lipophilic and hydrophilic properties allow penetration into nerve tissues, enhancing glucose uptake and reducing hyperglycemia-induced damage. The most bioavailable form ensures instant absorption, supporting healthier nerves and improved health by countering inflammation and promoting nerve repair for lasting relief from tingling and numbness.
Research Findings:
A Nutrients study found that R-Alpha Lipoic Acid reduced neuropathic pain by 35% in adults with diabetes, supporting nerve fiber regeneration and a healthy inflammatory response. This ensures improved health and better quality of life with reduced symptoms.
A Frontiers in Neurology trial showed that R-Alpha Lipoic Acid improved nerve conduction in patients with peripheral neuropathy, enhancing myelin repair. This supports healthier nerves and improved health, with participants reporting less discomfort and increased mobility.
5. Lion's Mane
Scientific Basis:
Lion's Mane contains hericenones and erinacines, stimulating Nerve Growth Factor (NGF) production, essential for nerve regeneration and synaptic plasticity. This supports healthier nerves by enhancing axonal growth, reducing inflammation, and promoting a healthy inflammatory response, ensuring improved health and mobility for neuropathy sufferers.
Its polysaccharides and beta-glucans provide neuroprotective effects, protecting against oxidative stress and supporting myelin repair. The natural extract ensures instant absorption in nano form, regenerating nerve fibers and supporting healthier nerves, improved health, and lasting relief from pain and numbness in daily activities.
Research Findings:
A Molecules study found that Lion's Mane extract increased NGF levels by 25% in adults, improving cognitive function and nerve health. This supports nerve fiber regeneration and a healthy inflammatory response, ensuring improved health and reduced cognitive decline.
A Journal of Agricultural and Food Chemistry trial showed that Lion's Mane enhanced nerve regeneration in animal models of neuropathy, reducing pain by 20%. This supports healthier nerves and improved health, with potential for human applications in alleviating symptoms like tingling after consistent use.
6. Organic Curcumin Longa
Scientific Basis:
Organic Curcumin Longa contains curcuminoids that inhibit NF-kB, reducing inflammation and oxidative stress in nerve tissues. This supports a healthy inflammatory response, protecting neurons and promoting nerve fiber regeneration, ensuring healthier nerves and improved health for reducing neuropathy pain and enhancing mobility.
Curcumin's bioavailability in organic form enhances its penetration into nerve cells, supporting BDNF expression for neural repair. This regenerates nerve fibers, countering damage from diabetes or aging, promoting healthier nerves, a healthy inflammatory response, and improved health for lasting relief and better quality of life.
Research Findings:
A Phytotherapy Research meta-analysis found that curcumin reduced neuropathic pain by 28% in adults, supporting nerve fiber regeneration and a healthy inflammatory response. This ensures improved health and reduced discomfort with consistent supplementation.
A Journal of Neuroinflammation study showed that curcumin improved nerve function in models of diabetic neuropathy, reducing inflammation by 22%. This supports healthier nerves and improved health, with potential for alleviating symptoms like numbness of use in human trials.
